CAN catalyzed one-pot synthesis of Imidazole derivatives in PEG-400 as HMG-CoA reductase inhibitor for benefit in atherosclerosis

Aim: The present study was intended to develop some novel imidazole derivatives via multi-component reaction catalysed by Ceric Ammonium Nitrate (CAN) in polyethylene glycol-400 (PEG-400) and its HMG-CoA reductase inhibitory activity for benefit in atherosclerosis. Methods: The one-pot synthesis has been achieved by taking benzyl, benzaldehyde, 3-amino-1, 2, 4triazole-5carboxylic acid (0.01 mol) in PEG-400 with CAN as a catalyst. These derivatives were subjected for anti-oxidant activity using DPPH free radical scavenging assay, together with determination of inhibitory activity against HMG-CoA reductase. Results: Among the tested compounds, compound 4i was identified as most promising compound exhibiting considerable quenching activity with IC50=3.1 ± 0.7 μM in DPPH assay. The compounds were further screened for HMG-CoA reductase inhibitory activity, where few analogues found to exhibit potent activity. Conclusion: All target derivatives have may exert beneficial effect in atherosclerosis via inhibition of HMG-CoA reductase together with anti-oxidant activity.